ProbiorinseTM is the first probiotic intended for nasal application.
Is there a microbiome of the nose?
The microbiome is defined as “The totality of microorganisms and their collective genetic material present in or on the human body” (Dictionary.com; 2018). As we have about 10 times as many microbial cells in or on our bodies as human cells, these can play an important role in maintenance of health and development of disease. Every organ and anatomic site on the body has bacterial colonies termed a ‘microbiome’. This varies according to the location and can differ greatly between them depending on prevailing local conditions: warm or cold, damp or dry, etc.
While the gut microbiome has received the lion’s share of attention, we are still learning important facts about microbiome of other sites such as the skin, reproductive passages, and the nose. Researchers have identified that a bacterial imbalance is present in patients with allergies and with chronic rhinosinusitis, with decreased beneficial species and a decrease in diversity, or variety of organisms recovered.
It is believed that the delicate balance in the composition of these bacterial communities can be disturbed by inflammation, viral infections or allergies, leading to an imbalance in bacteria species termed ‘dysbiosis’. This imbalance is believed to impair the protective and health-maintaining properties of the microbiome, thereby contributing to development and persistence fo disease. For these reasons, researchers and clinicians are increasingly attempting to manipulate the microbiome in various fashions, including the use of probiotics.
Until recently, there have been no probiotics available for intranasal use. Fortunately, now ProbiorinseTM offers a novel treatment alternative to the nasal and sinus sufferer. ProbiorinseTM is unique in combining a the benefits of saline nasal irrigation with the addition of a probiotic bacteria. By incorporating freeze-dried probiotic Lactocccus lactis W136 to the convenient individual dose-packs of buffered saline mixture, fresh probiotic is reconstituted at the time of making of the solution, so that fresh probiotic rinse solution is used each time.